BEST CLI is a randomised clinical trial of open surgical bypass vs endovascular revascularisation for chronic limb-threatening ischaemia, published in the NEJM in November 2022. 

In this video, the BEST CLI trial Chief Investigators Dr Alik Farber and Dr Matthew Menard discuss the findings with Dan Carradice, Vascular Surgical Specialty Lead of the Royal College or Surgeons of England, and Thanos Saratzis, co-chair of the VSGBI Peripheral Arterial Disease Special Interest Group.

They take a deeper dive into some of the controversies associated with the study including issues around external validity; including the quality of endovascular treatment and best medical management. They also discuss the challenges in delivering high quality large RCTs such as this and conclude with a key points summary.